You can lose money by investing in the Fund. Chemokines in tumor progression and metastasis. The polynucleotides of the present invention which code for the L and H chains of the human anti-HBs antibody immunoglobulin have been verified to have base sequences that are represented by the following formulae I and II respectively, as estimated from the sequence of the primary structure of cDNA that was cloned from the human anti-HBs antibody producing B cell line that was transformed with Epstein-Barr virus hereunder abbreviated Hbs 9 604 081 EBV See SEQ.
Recently, Li et al. When expressing antibody molecules that have been reconstructed using bacteria, especially E. Stated more specifically, the present invention relates to polynucleotides that code for the L and H chains of the human anti-HBs antibody immunoglobulin, as well as polynucleotides coding code for polypeptides that comprise portions of said L and H chains, respectively, which when expressed are reasonably effective in passive immunity e.
The promoters in expression vectors are selected depending upon host cells; useful bacterial promoters include lac promoter, trp promoter, etc.
Introduction into plasmids, the establishment of transformed cell lines, the culture Hbs 9 604 081 those cell lines, and other operations can be performed in accordance with routine genetic recombination techniques.
Journal of clinical oncology: It was therefore verified the H chain could be expressed in E. However, similar results were not identified among individuals who lacked an immune response to HBV.
Associations between B-cell non-Hodgkin lymphoma and exposure, persistence and immune response to hepatitis B. Prevention and control of hepatitis B in China.
Minicells were prepared by the conventional procedure Roosen K. An expression plasmid containing the polynucleotide recited in claim 1. In addition, a 0.
International journal of cancer. Also usable are other probes that have been designed on the basis of the nucleotide sequence that is set forth in formula I or II.
The amino acid composition of the cDNA is shown in Table 1 for both the estimated and measured values.
In the case of cloning from the genome, the various primer nucleotides or probe nucleotides that were used in the examples that follow can be used as probes for the selection of genomic DNA fragments.
A total of 81 primary positive clones were obtained and 33 of them were strongly positive. Three major types are known as antibodies against hepatitis B virus and they include an anti-HBs antibody, as well as an antibody against Hbs 9 604 081 core antigen HBc within the virus particle and an antibody against the e antigen HBe which is held to be contained in the core antigen.
The risk that debt securities will decline in value because of changes in interest rates. Disclosed herein are the polynucleotides represented by formulae I and II as the nucleotide sequences of genes coding for the L and H chains of the anti-HBs antibody, but they are by no means intended to limit the polynucleotides of the present invention.
As a result, ca. Nature, ; The anti-HBs antibody coding genes of the present invention can also be prepared by chemical synthesis. Host cells are in no way limited but they include, for example, bacteria, yeasts and other fungi, the cultured cells of humans and other animals, and the cultured cells of plants.
Thinking that the production of a human immunoglobulin with high titer and selectivity in microorganisms would be useful for the development of a pharmaceutical preparation of immunoglobulin for use in passive immunotherapy, the present inventors repeated intensive studies with a view to accomplishing large-scale production of the human monoclonal anti-HBs antibody in microorganisms.The aim of this study was to evaluate, in adults, the immunogenicity of six hepatitis B vaccines with different doses or different manufacturers in the Chinese market and to provide evidence to.
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